"Mechanical thrombectomy in M1 and M2 segments of middle cerebral arteries: A meta-analysis of prospective cohort studies"

• Posted by: Admin
• Rabu, 14 Juni 2023
• Has been read 346 time(s)

Students of the Medical Profession Study Program, Faculty of Medicine, Udayana University and Prof. Ngoerah General Hospital, Bryan Gervais de Liyis, consisting of Stevanus Christian Surya and dr. Eric Hartono Tedyanto who was guided by dr. Nyoman Angga Krishna Pramana, Sp.N, FINR, FINA and Dr. dr. I Putu Eka Widyadharma, M.Sc, Sp.S(K) successfully published the results of the meta-analysis in an article entitled “Mechanical thrombectomy in M1 and M2 segments of middle cerebral arteries: A meta-analysis of prospective cohort studies”. The Journal of Clinical Neurology and Neurosurgery published by Elsevier is indexed by Scopus Q2.

Studies show that endovascular therapy is superior to intravenous thrombolysis in treating M1-segment MCA occlusions; however, the effectiveness of mechanical thrombectomy in MI-segment occlusions vs. M2 is not clear. The meta-analysis was performed by searching the database from January 2016 to January 2023, regardless of language barrier. Analysis of the pooled data of outcome, pre-existing medical comorbidities, and baseline score was performed. Six prospective cohort studies with a total of 6356 patients were included. Patients with M2 occlusions had significantly lower NIHSS baseline mean on admission. In contrast, patients with M1 occlusions had lower ASPECTS scores on admission. No significant differences were found between segments in terms of pre-existing medical comorbidities, mortality at 90 days, and bleeding events within 24 hours. Patients with M2 occlusions are more likely to have a good outcome after therapy. The rate of successful recanalization is relatively higher among patients with M1 occlusion. Functional outcome at 90 days was better in M2 occlusion patients, while successful recanalization rate was higher in M1 occlusion patients. No significant differences were found in rates of death or bleeding events. These results suggest that mechanical thrombectomy is a safe and effective treatment for MCA occlusion of the M1 and M2 segments.

Despite differences in recanalization rates and good functional outcomes, the findings of this study imply that mechanical thrombectomy has relatively good efficacy and safety in recanalization of occlusions in the M1 and M2 segments of the MCA.

Articles can be accessed via the link: https://authors.elsevier.com/c/1hDFW155ZJ-Q0N