Doctor of Medical Sciences Proves Delirium as a Predictor of Death and Length of Hospitalization in Elderly Patients with Community-Acquired Pneumonia

• Posted by: Admin
• Selasa, 8 April 2025
• Has been read 49 time(s)

Doctor of Medical Sciences Proves Delirium as a Predictor of Death and Length of Hospitalization in Elderly Patients with Community-Acquired Pneumonia

Located in the Postgraduate Hall, 3rd Floor of the Postgraduate Building, Udayana University, the Doctoral Program in Medical Sciences, Faculty of Medicine, Udayana University held an open Doctoral Promotion examination with the candidate for promovenda, dr. Ni Ketut Rai Purnami, Sp.PD-KGer., with the dissertation title "Delirium is a Predictor of Death and Length of Hospitalization in Elderly Patients with Community-Acquired Pneumonia, Through a Study: Malondialdehyde Levels, Tissue Factor, and Plasma D-Dimer" (3/27/2025)

Community-acquired pneumonia is a major cause of morbidity and mortality in elderly patients, so it is important to understand the predictors that influence this condition, such as oxidative stress, hypercoagulability, thrombosis, and delirium, to improve diagnosis, treatment, and clinical outcomes of patients and reduce the risk of serious complications. The purpose of this study was to prove that delirium, high levels of malondialdehyde, tissue factor, and plasma D-dimer are predictors of death and long hospitalization in elderly patients with community-acquired pneumonia and the underlying mechanisms.

A survival analysis study was conducted with a single-arm prospective cohort design in 39 elderly patients with community-acquired pneumonia. Data collection was carried out through interviews (delirium assessment) and laboratory examinations of the predictors: levels of malondialdehyde, tissue factor, and plasma D-dimer. Data were analyzed descriptively and inferentially with bivariate analysis using the Kaplan-Meier curve and log-rank test, and multivariate analysis with the Cox proportional model, with a significance level of p < 0.05.

The results of the analysis showed that delirium was proven to be a significant predictor of death, with a hazard ratio (HR) of 14.01 (p = 0.011). In addition, delirium was also associated with longer hospitalization duration, with HR 5.54 (p = 0.029). Meanwhile, high levels of malondialdehyde, tissue factor, and plasma D-dimer were not significantly associated with death and length of hospitalization of patients (p > 0.05).

From the results of this study, it was concluded that delirium is a strong predictor of death and long hospitalization, so special attention is needed from medical personnel in elderly patients suffering from community-acquired pneumonia and also accompanied by delirium.

This examination was led by the Dean of the Faculty of Medicine, Udayan University, Prof. Dr. dr. Komang Januartha Putra Pinatih, M.Kes., with the examination team:

1. Prof. Dr. dr. R.A. Tuty Kuswardhani, Sp.PD.,KGer.M. Kes.,MH (Promoter)

2. Dr. dr. I Gusti Putu Suka Aryana, Sp.PD,K-Ger,FINASIM (Co-promoter I)

3. Dr. dr. I Wayan Niryana, M.Kes.,Sp.BS(K) (Co-promoter II)

4. Prof. Dr. dr. I Made Jawi, M.Kes

5. Prof. Dr. dr. Ketut Suastika, Sp.PD-KEMD

6. Prof. Dr. Ir. Ida Bagus Putra Manuaba, M.Phil

7. Prof. Dr. dr. I Wayan Putu Sutirta Yasa, M.Si

8. Prof. Dr. dr. Ketut Suryana, Sp.PD-KAI., FINASIM

9. Prof. Dr. dr. I Made Sudarmaja, M.Kes

10. Dr. dr. Ni Putu Sriwidyani, Sp.PA.,Subsp.S.M.(K)

With academic invitation:

1. Dr. dr. I Nyoman Astika, Sp.PD-KGer,FINASIM

2. Dr. dr. I Made Pande Dwipayana, Sp.PD-KEMD,FINASIM

3. Dr. dr. I Ketut Mariadi, Sp.PD-KGEH,FACG,FINASIM

4. Dr. dr. Luh Oliva Saraswati Suastika, Sp.JP Eko.(K), FIHA

5. Dr. dr. Ni Made Renny Anggreni Rena, Sp.PD., KHOM., FINASIM

In this exam, Dr. dr. Ni Ketut Rai Purnami, Sp.PD-KGer., was declared to have passed as the 454th Doctoral Graduate of the Doctoral Program in Medical Sciences, Faculty of Medicine, Udayana University with Cumlaude predicate

Gallery