Delivers Luh Putu Widiastini, S.Si.T., M.Kes to Receive Doctoral Degree for Researching the Potential of Giving Moringa Leaf Ethanol Extract in Increasing Male Fertility

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• Rabu, 2 Februari 2022
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Wednesday, 2 February 2022

A Doctoral Promotion was held in the Prof. dr. I Goesti Ngoerah Gde Ngoerah with promovenda candidate Luh Putu Widiastini, S.Si.T., M.Kes with the dissertation title "The Administration of Moringa Leaf Ethanol Extract (Moringa Oleifera) Increases Progressive Motility of Spermatozoa and Lowers 8-Hydroxydeoxyguanosine (8 (Rattus Norvegius). Men's reproductive aging is marked by a gradual loss of physiological integrity, which causes damage to the testes, epididymis, and other reproductive organs. Oxidative stress, which is defined as an imbalance of reactive oxygen species (ROS) and antioxidants, is the primary cause of this process. Supraphysiological levels of ROS can impair spermatozoa motility, damage mitochondria, and compromise DNA integrity, resulting in a rise in 8-hydroxydeoxyguanosine (8-OHdG) levels and infertility. Moringa leaves contain qualities, benefits, and a high nutritional value, earning it the nickname "Miracle Tree." Moringa leaves also have a high antioxidant content, which can counteract and protect cells against ROS attacks.

The results obtained from this study using statistical tests using Independent Sample T Test on Spermatozoa Progressive Motility data and Mann Whitney on Spermatozoa 8-hydroxydeoxyguanosine levels (8-OHdG) data with a significance value of 0.05, the results obtained significantly increased Spermatozoa Progressive Motility in the treatment group compared to the control group (p0.05), and the decrease in levels of 8-hydroxydeoxyguanosine (8-OHdG) Spermatozoa significant.

In mice (Ratus Norvgicus) of advanced age, administration of Moringa oleifera leaf ethanol extract at a concentration of 50 mg/kg BW can increase sperm motility and decrease 8-hydroxydeoxyguanosine (8-OHdG), a marker of mtDNA damage. There has been no research to the best of the researchers' knowledge that has confirmed the role of flavonoids and ascorbic acid found in the ethanolic extract of Moringa leaves in enhancing sperm motility and lowering 8-hydroxydeoxyguanosine (8-OHdG) in old-age mice (Ratus Norvgicus).

The antioxidant content of Moringa (moringa oleifera) leaves, which includes phenolic compounds, flavonoids, and ascorbic acid (Vitamin C), works to neutralize free radicals, preventing oxidative damage to most biomolecules and providing significant protection against oxidative damage. This study shows that ethanol extract from Moringa oleifera (Moringa Oleifera) leaves can boost Spermatozoa Progressive Motility while lowering Spermatozoa 8-hydroxydeoxyguanosine (8-OHdG) levels.

The Doctoral Promotion this time was led directly by the Dean of Medical Faculty Unud Dr.dr.Komang Januartha Putra Pinatih, M.Kes, with a team of examiners:

1. Prof. Dr. dr. I Nyoman Mangku Karmaya, M.Repro., PA (K) (Promoter)

2. Dr. dr. Bagus Komang Satriyasa, M. Repro (Copromotor I)

3. Dr. drh. WayanFree, M.Kes (Copromotor II)

4. Prof. Dr. dr. I Made Bakta, SpPD-KHOM

5. Prof. Dr. Ir. I B Putra Manuaba, M.Phill

6. Prof. Dr. dr. J . Alex Pangkahila, M.Sc., Sp.And (KSAAM) AIFO-K

7. Prof. Dr. dr. I Wayan Putu Sutirta Yasa, M.Si

8. Prof. Dr. dr. I Made Jawi, M.Kes

9. Dr. dr. A A Ngurah Jaya Kusuma, SpOG(K)., MARS

10. Dr. dr. I Nyoman Wande, S.Ked., SpPK(K)

While the academic invitations are:

1. Dr. dr. I Made Sudarmaja, M.Kes

2. Dr. dr. A A Ngurah Subawa, M. Si

3. Dr. dr. Ni Made Linawati

4. Dr. dr. Agung Wiwiek Indrayani, M.Kes

5. dr. I Made Winarsa Ruma, S.Ked., Ph.D

Dr. Luh Putu Widiastini, S.Si.T., M.Kes was declared the 338th Graduate of the Doctoral Study Program of Medical Sciences, Faculty of Medicine, Udayana University with the CUMLAUDE predicate.

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