Doctor of Medical Science Studies the Potential of Sweet Potato Leaf Extract Granules in Improving Blood Glucose Levels

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• Rabu, 12 Maret 2025
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Doctor of Medical Science Studies the Potential of Sweet Potato Leaf Extract Granules in Improving Blood Glucose Levels

Located in the Postgraduate Hall, 3rd Floor of the Postgraduate Building, Udayana University, the Doctor of Medical Science Study Program, Faculty of Medicine, Udayana University held an open Doctoral Promotion examination with promovenda candidate, apt. Ni Nyoman Wahyu Udayani, S.Farm., M.Sc., with the dissertation title "Potential of Sweet Potato Leaf Extract Granules (Ipomoea Batatas L.) to Improve Blood Glucose Levels, HbA1c, C-Peptide, Glucagon Like Peptide-1, Malondialdehyde and the Number of Pancreatic Beta Cells in Male White Rats (Rattus Norvegicus) Diabetes". (11/3/2025)

Diabetes mellitus (DM) is a group of metabolic diseases characterized by increased blood glucose levels above normal values ​​due to abnormalities in insulin secretion, insulin function or both. The use of drugs is currently not optimal, so alternative treatments using herbal medicinal plants are needed. This study aims to see the effect of administering sweet potato leaf extract granules (Ipomoea batatas L.) in reducing blood glucose levels, malondialdehyde, HbA1c, increasing C-peptide levels, GLP-1, and improving pancreatic histopathology.

The research method was an experimental randomized post-test only control group design. This study used 30 male white rats divided into 6 groups, namely normal control (KN), negative control ((K (-), CMC Na 0.1%), positive control ((K (+), Glibenclamide 0.45 mg / kgBW), extract granule treatment group with doses of 250 (P1), 500 (P2), and 750 mg / kgBW (P3). Streptozotocin was given a dose of 40 mg / kgBW, with observation for 21 days. Data were analyzed statistically using One Way Anova followed by the Post Hoc LSD test to determine differences in blood glucose levels, malondialdehyde, HbA1c, C-peptide levels, GLP-1, and the number of pancreatic beta cells between groups.

The results showed that KN blood glucose levels were 95.50 ± 9.04; K (-) was 347.20 ± 38.22; K (+) was 110.00 ± 7.96; P1 was 142.20 ± 33.82; P2 of 123.20 ± 33.82 and P3 of 111.60 ± 12.30. HbA1C levels were obtained that HbA1C levels K (N) were 5.92%, K (-) of 7.46%, K (+) of 6.00%, P1 of 6.05%, P2 of 6.11% and P3 of 6.08%. C-Peptide levels K (N) were 44.71 ± 1.99, K (-) 32.13 ± 2.71; K (+) 47.96 ± 4.46, P1 of 45.44 ± 2.87, P2 of 55.66 ± 2.48 and P3 of 48.74 ± 1.09%.

GLP-1 levels K(N) were 1,683.23±204.13; K(-) was 1,365.33±189.20; K(+) was 1,627.66±154.63, P1 was 1,627.33±191.11, P2 was 1,612.66±176.76 and P3 was 1,763.99±529.87%. The average number of beta cells in the K(N) group was 202.00±18.47; K(-) was 43.60±16.89, K(+) was 151.40±5.54; P1 was 96.50±6.54; P2 was 116.20±7.75 and P3 was 158.00±9.97.

The conclusion of this study was that the administration of sweet potato leaf granules (Ipomoea batatas L.) caused blood sugar levels, HbA1c and MDA to be lower than the control and C-peptide levels, GLP-1 and the number of pancreatic beta cells were higher than the control in diabetic white rats (Rattus norvegicus).

This examination was led by the Dean of the Faculty of Medicine, Udayan University, Prof. Dr. dr. Komang Januartha Putra Pinatih, M.Kes., with the following examiner team:

1. Prof. Dr. rer. Nat. Drs. I Made Agus Gelgel Wirasuta, Apt, M.Si (Promoter)

2. Prof. Dr. dr. I Made Jawi, M.Kes (Co-promoter I)

3. Dr. dr. Made Ratna Saraswati, Sp.PD,KEMD.,FINASIM (Co-Promoter II)

4. Prof. Dr. dr. I Wayan Putu Sutirta Yasa, M.Si

5. Prof. Drs. Yan Ramona, M.App.Sc., Ph.D

6. Prof. Dr. dr. I Made Sudarmaja, M.Kes

7. Dr. dr. Desak Made Wihandani, M.Kes

8. Dr. dr. Dyah Kanya Wati, Sp.A (K)

9. Dr.rer.nat.dr.Ni Nyoman Ayu Dewi,M.Si

10. Dr.apt. Ketut Agus Adrianta, S.Farm.,M.Biomed

With academic invitation:

1. Desak Ketut Ernawati, S.Si,Apt., P.G.Pharm.,M.Pharm., Ph.D

2. Dr. Dra. Ida Ayu Alit Widhiartini, Apt.,M.Si

3. Dr. rer.nat. apt. Ni Putu Ariantari, S.Farm., M.Farm

4. Dr. Ns. Desak Made Widyanthari, S.Kep., M.Kep., Sp.Kep.MB

5. Dr. apt. I Made Agus Sunadi Putra, S.Si.,M.Biomed

In this exam, Dr. apt. Ni Nyoman Wahyu Udayani, S.Farm., M.Sc., was declared to have passed as the 448th Doctoral Graduate of the Doctoral Program in Medical Sciences, Faculty of Medicine, Udayana University with the predicate Very Satisfactory

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