Research on Percutaneous Coronary Intervention in Patients with Chronic Total Obstruction of Coronary Vessels leads dr. I Made Junior Rina Artha, Sp.JP to Receive Doctoral Degree

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• Kamis, 20 Januari 2022
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Thursday, January 20, 2022

Located in the Prof. dr. I Goesti Ngoerah Gde Ngoerah room, there has been a Doctoral Promotion which was carried out in a hybrid manner for the candidate dr. I Made Junior Rina Artha, Sp.JP with the dissertation title "Percutaneous Coronary Intervention Actions (PCI) to Reduce Matrix Metalloproteinase 9 (MMP-9) Levels, Soluble Suppression of Tumorigenicity 2 (sST2), N-Terminal Pro B-Type Natriuretic Peptides ( NT PRO BNP), and Improving the Quality of Angina in Patients with Chronic Total Obstruction (CTO) of Coronary Vessels.”

Chronic total occlusion (CTO) is an angiographic picture of total occlusion without blood flow which is estimated to have lasted at least 3 months, and the approach to using percutaneous coronary intervention therapy (PCI) and without PCI is still controversial in terms of clinical outcomes of cardiovascular events. major and quality of life between the use of PCI and without PCI. This study attempted to provide an overview of the molecular criteria for the levels of MMP-9, sST2, and NT-pro BNP as remodeling, inflammatory, and atherosclerotic markers as well as changes in the quality of life of angina components in patients with CTO who underwent PCI procedures compared to those without PCI.

The results of this study showed that PCI decreased serum MMP-9 levels, decreased serum sST2 levels, and decreased serum NT-Pro BNP levels. MMP-9 levels were lower in the group undergoing PCI compared to those without PCI, as were the levels of sST2 and NT pro BNP. And there was an improvement in the quality of life of the angina component better in the PCI group compared to without PCI. This study proves that PCI is able to provide changes at the molecular level, i.e. reducing levels of MMP-9, NT-pro BNP, and sST2, as well as providing an improvement in the quality of life of angina components in CTO patients compared to without PCI.

The novelty of this research is to provide an understanding of the impact of the PCI procedure at the cellular level which is characterized by changes in biomarkers (MMP-9, sST2, and NT-pro BNP) as well as improvements in the quality of life of angina components. And this study seeks to confirm the controversy regarding the therapeutic approach in CTO patients who undergo PCI or without PCI, and confirms the choice of PCI therapy in CTO cases.

The open doctoral defense  was led directly by the Dean of the Faculty of Medicine, Dr. dr. Komang Januartha Putra Pinatih, M.Kes with a team of examiners:

1. Prof. Dr. dr. I Wayan Wita, Sp.JP (K) (Promoter)

2. Prof. Dr. dr. I Made Bakta, Sp.PD-KHOM (Copromotor I)

3. Prof. Dr. Ir. Ida Bagus Putra Manuaba, M. Phil (Copromotor II)

4. Prof. Dr. dr. J . Alex Pangkahila, M.Sc., Sp.And (KSAAM) AIFO-K

5. Prof. Dr. dr. I Made Jawi, M.Kes

6. Prof. drh. I Nyoman Mantik Astawa, Ph.D

7. Prof. Dr. dr. I Wayan Putu Sutirta Yasa, M.Si

8. Prof. dr. Mohammad Saifur Rohman, Sp.JP(K), Ph.D

9. Prof. Dr. dr. A.A. Wiradewi Lestari, S.Ked., Sp.PK(K)

10. Prof. dr. I Made Ady Wirawan, S.Ked, MPH., Ph.D

While the academic invitations are:

1. Dr.rer.nat. dr. Ni Nyoman Ayu Dewi, M.Si

2. dr. Ni Nengah Dwi Fatmawati, S.Ked., Sp.MK(K)., Ph.D

3. Dr. dr. I Wayan Eka Sutyawan, Sp. M

4. Dr. dr. Made Lely Rahayu, Sp.THT.KL(K)., FICS

5. Dr. dr. I Made Pande Dwipayana, Sp.PD-KEMD, FINASIM

In this doctoral defense, Dr. dr. I Made Junior Rina Artha, Sp.JP graduated as the 335th Graduate of the Doctoral Study Program at the Faculty of Medicine, Udayana University with the predicate VERY SATISFACTORY.

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