Soursop Leaf Extract Shows Potential for Additional Therapy for Diabetes Mellitus through Antioxidant and Anti-inflammatory Mechanisms

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• Rabu, 21 Mei 2025
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Soursop Leaf Extract Shows Potential for Additional Therapy for Diabetes Mellitus through Antioxidant and Anti-inflammatory Mechanisms

Located in the Postgraduate Hall room, Lt. III Postgraduate Building, Udayana University, Doctor of Medical Sciences Study Program, Faculty of Medicine, Udayana University held an open examination for Doctoral Promotion with promovenda candidate, dr. Dewa Ayu Agung Alit Suka Astini, M.Si., with the dissertation title "The Effect of Soursop Leaf Ethanol Extract (Annona Muricata L.) on Adiponectin, SOD, TNF-α, and Musculoaponeurotic Fibrosarcoma Aoncogene Homolog A Levels in Diabetes Mellitus Mouse Models". (20/5/2025)

Diabetes mellitus is a metabolic disease characterized by oxidative stress and systemic inflammation, involving biomarkers such as adiponectin, SOD, TNF-α, and MaFA. New therapeutic approaches are needed to effectively manage this condition. This study aims to evaluate the effect of soursop leaf ethanol extract (Annona muricata L.) on adiponectin, SOD, TNF-α, and MaFA levels in a rat model of diabetes mellitus, as well as to analyze the relationship between biomarkers using path analysis.

The study was conducted on Wistar rats divided into control and treatment groups that were given soursop leaf extract for 21 days. Measurement of adiponectin, SOD, TNF-α, and MaFA levels was done using ELISA method. Differential test analysis was performed using independent t-test for MaFA levels and Mann-Whitney test for adiponectin, SOD and TNF-α levels.

The results showed that adiponectin and SOD levels were significantly higher in the treatment group given soursop leaf extract compared to the control (p=0.006 and p=0.001, respectively), and TNF-α levels were significantly lower in the treatment group (p=0.027). MaFA levels showed no significant difference (p=0.116), but tended to be higher in the treatment group. Path analysis revealed that SOD played a role in reducing TNF-α through increasing adiponectin, and adiponectin played a role in increasing MaFA through decreasing TNF-α. In addition, SOD indirectly increased MaFA through increasing adiponectin and decreasing TNF-α.

These findings support the potential of soursop leaf extract as an adjunctive therapy in the management of diabetes mellitus through antioxidant and anti-inflammatory mechanisms. This study provides a basis for the development of broader natural plant-based therapies in the treatment of diabetes mellitus.

The examination was chaired by the Dean of FK Unud, Prof. Dr. Komang Januartha Putra Pinatih, M.Kes, with a team of examiners:

1. Prof. Dr. I Wayan Putu Sutirta Yasa, M.Si (Promoter)

2. Prof. Dr. dr. I Made Jawi, M.Kes (Copromoter I)

3. Dr. dr. I Nyoman Wande, S.Ked.,Sp.PK(K) (Kopromotor II)

4. Prof. Dr. dr. I Gusti Ayu Sri Mahendra Dewi, Sp.P.A.,Subsp.O.G.P.(K)

5. Prof. Dr. dr. Sianny Herawati, Sp.PK, Subsp.BDKT(K), Subsp.NR(K)

6. Prof. Dr. dr. A.A Ngurah Subawa, M.Si., Sp.KKLP

7. Dr. dr. Ni Made Linawati, S.Ked., M.Si

8. Dr. dr. Agung Wiwiek Indrayani, S.Ked.,M.Kes

9. Dr. dr. Dewa Ayu Putri Sri Masyeni, Sp.PD-KPTI

10. Dr. dr. I Made Muliarta, S.Ked., M.Kes

By academic invitation:

1. Dr. dr. I Nyoman Putu Riasa, Sp.BP RE (K)

2. Dr. dr. I Gusti Ayu Widianti, M.Biomed

3. Dr. dr. Kadek Mulyantari, Sp.PK, Subsp.BDKT(K)

4. Dr. dr. Asri Lestarini, M.Sc

5. Dr. dr. Komang Trisna Sumadewi, M.Biomed

In this exam, Dr. dr. Dewa Ayu Agung Alit Suka Astini, M.Si., was declared to have graduated as the 460th Doctoral Graduate of the Medical Science Doctoral Study Program, Faculty of Medicine, Udayana University with the title of With Honors.

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