The Role of Vitamin D in Preventing Premature Labor

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• Selasa, 18 Januari 2022
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Tuesday, January 18, 2022

Located in the Prof. dr. I Goesti Ngoerah Gde Ngoerah, there has been a Doctoral Promotion exam which was carried out in a hybrid manner on behalf of dr. Anak Agung Gede Putra Wiradnyana, Sp.OG (K)-KFM with the dissertation title "Low Maternal Serum Vitamin D Levels, Positive p38MAPK Expression in the Amniotic Membrane, and High Maternal Serum IL-8 Levels in Pregnant Women as Risk Factors for Childbirth Preterm at Sanglah Hospital, Denpasar."

Preterm labor is delivery that occurs before 37 weeks' gestation. In the last two decades, preterm delivery is still a health problem for pregnant women related to the prevalence, morbidity, and mortality of mothers and babies. All of these things can cause the low quality of human resources in the future.

The results obtained from this study were low maternal serum vitamin D levels, positive p38MAPK expression in the amniotic membrane, and high maternal serum IL-8 levels were risk factors for preterm delivery, where low maternal serum vitamin D levels in pregnant women were a factor. the risk of preterm delivery was 14 times (OR = 13.60; 95% CI = 3.25 – 56.95; p = 0.01), positive p38MAPK expression in the membranes of pregnant women as a risk factor for preterm delivery was 9 times (OR = 8.80; 95% CI = 2.50 – 30.97; p = 0.01), high maternal serum IL-8 level as a risk factor for preterm delivery was 15 times (OR = 15.40; 95% CI = 4.08 – 58.17; p = 0.01), and in multivariate analysis using the simultaneous logistic regression method, it was found that high maternal serum IL-8 levels were the highest risk factor followed by positive p38MAPK expression in membranes and maternal serum vitamin D levels low ng.

The development of new knowledge (novelty) from this study is that low maternal serum Vitamin D levels, positive p38MAPK expression in the amniotic membrane, and high maternal serum IL-8 levels in pregnant women simultaneously as risk factors for preterm labor are new findings in this study. This is because it has never been done or obtained empirical data reported in other studies, thus providing new evidence in the pathogenesis of a more holistic mechanism of preterm labor.

The implication of the results of this study is that the examination of maternal serum vitamin D and IL-8 levels can be used as a screening in the treatment of pregnant women who are at high risk of preterm delivery, can be given vitamin D supplementation with a dose of 400 IU daily for pregnant women to prevent preterm labor. where this is a cheap and safe and affordable prevention that can substantially reduce the occurrence of preterm labor, and further research can be carried out on the role of p38MAPK in preterm labor, because in this study it was proven that p38MAPKb has a direct relationship with IL-8 secretion and affects SASP secretion. on the mechanism of preterm labor.

The open exam this time was led directly by the Dean of Medical Faculty Unud - Dr.dr.Komang Januartha Putra Pinatih, M.Kes with a team of examiners:
1. Prof. Dr. dr. I Ketut Suwiyoga, Sp.OG(K)Onk (Promoter)
2. Prof. Dr. dr. I Made Jawi, M.Kes
(Copromoter I)
3. Prof. drh. I Nyoman Mantik Astawa, Ph.D (Copromotor II)
4. Prof. Dr. dr. I Made Bakta, Sp.PD-KHOM
5. Prof. Dr. dr. J. Alex Pangkahila, M.Sc., Sp.And
6. Prof. Dr. Ir. Ida Bagus Putra Manuaba, M.Phil
7. Prof. Dr. dr. I Dewa Made Sukrama, M.Si., Sp.MK (K)
8. Dr. dr. A A. Ngurah Jaya Kusuma, Sp.OG (K) MARS
9. Dr. dr. I Nyoman Gede Budiana, Sp.OG (K)
10. Dr. dr. I Wayan Niryana, M.Kes, SpBS(K)

While the academic invitations are:
1. Dr. dr. Tjok Gde Agung Senapathi, Sp.An.,KAR
2. Dr. dr. I Nyoman Wande, S.Ked.,Sp.PK(K)
3. Dr. dr. I Nyoman Bayu Mahendra, Sp.OG(K)Onk
4. Dr. dr. Tjok Gde Agung Suwardewa, Sp.OG(K)-KFM
5. Dr. dr. I Gede Ngurah Harry Wijaya Surya, Sp.OG(K)

In this exam, Dr. dr. Anak Agung Gede Putra Wiradnyana, Sp.OG (K)-KFM graduated as the 334th Graduate of the Doctoral Study Program of Medical Sciences, Faculty of Medicine, Udayana University with CUMLAUDE predicate

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