After Demonstrating the Potential of Cinnamon Bark Extract in Controlling Blood Sugar Levels, Anak Agung Bawa Putra to Obtain a Doctorate in Medicine.

• Posted by: Admin
• Kamis, 28 Juli 2022
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Located in the third floor courtroom, Postgraduate Building, Udayana University, Denpasar, a Doctoral Promotion exam was held with promovendus candidate Anak Agung Bawa Putra, S.Si., M.Sc., who raised the dissertation title "The Effect of Nano Chitosan-Tripolyphosphate Bark Extract Cinnamon Against Changes in Malondialdehyde, Superoxide Dismutase, and Glutathione Peroxidase in Hyperglycemic Wistar Mice". (28/7/2022)

Hyperglycemia plays an important role in the development and progression of diabetes mellitus complications through various mechanisms, including increased oxidative stress. Oxidative stress develops when the production of reactive oxygen-derived free radicals exceeds the cell's antioxidant defense mechanism, resulting in the formation of lipid peroxides and discontinuous fatty acid chains into malondialdehyde and a decrease in superoxide dismutase and glutathione peroxidase activity.

The limitation of using crude extracts from medicinal plants orally is because of their low bioavailability so that the effect is very slow. The manufacture of nano-chitosan-tripolyphosphate-cinnamon bark extract using the ionic gelation method can be applied as a nano-herbal to control the blood sugar of hyperglycemic wistar rats by observing changes in biomarkers of malondialdehyde, superoxide dismutase, and glutathione peroxidase.

The results of the identification determination stated that the cinnamon plant sample included the type of Cinnamomum burmanni Blume. The results of the phytochemical test of cinnamon bark extract showed a positive content of polyphenols, flavonoids, alkaloids, and terpenoids.

Characterization of chitosan-tripolyphosphate-cinnamon bark extract observed that there has been encapsulation of the active substance from cinnamon bark extract on the chitosan-tripolyphosphate nanoframe with the appearance of spectra that characterize the absorption of N-H, P-O groups, and a shift in absorption for the -OH, C-C groups. , C=C, and C-O. Zeta potential characterization and particle size strongly support nano chitosan-tripolyphosphate-cinnamon bark extract as an active substance delivery system with a zeta potential of -25.80 mV and a particle size of 455.20 nm.

Administration of nano chitosan-tripolyphosphate-cinnamon bark extract in hyperglycemic rats resulted in lower blood sugar levels and malondialdehyde levels, while superoxide dismutase and glutathione peroxidase levels were higher than controls.

The development of new science (novelty) from this research is the modification of the active substance from the cinnamon bark extract into nano-extracts with a diameter of nanometers with a zeta potential value of -25.80 mV and a particle size of 455.2 nm which can be used as a delivery system for active substances that cause lower blood sugar and malondialdehyde levels and higher levels of superoxide dismutase and glutathione peroxidase compared to controls in hyperglycemic wistar rats.

The implication of this research is that the active substance content of cinnamon bark extract works to neutralize free radicals thereby preventing oxidative damage to most biomolecules and providing significant protection against oxidative damage thereby reducing malondialdehyde and increasing superoxide dismutase and guttation peroxidase.

This study proves that the active substance of cinnamon bark extract encapsulated in the framework of chitosan-tripolyphosphate can reduce blood sugar and malondialdehyde levels and increase levels of superoxide dismutase and glutathione peroxidase.

The exam was led by the Vice Dean for Student Affairs and Information, Prof. dr. I Md. Ady Wirawan, MPH., Ph.D. with the test team:

1. Prof. Dr. dr. I Wayan Putu Sutirta Yasa, M.Si (Promoter)

2. Prof. Dr. dr. I. B. Putra Manuaba, M. Phil (Copromotor I)

3. Dr. Drs. I Made Siaka, M.Sc. (Hons) (Copromotor II)

4. Prof. Dr. dr. I Made Bakta, Sp.PD-KHOM

5. Prof. Dr. dr. I Made Jawi, M.Kes

6. Prof. Dr. Drs. I Made Oka Adi Parwata, M.Si

7. Prof. Dr. Dra. Ni Made Suaniti, M.Si

8. Dr. dr. I Made Sudarmaja, M.Kes

9. Prof. Dr. Dra. Wiwik Susanah Rita, M.Si

10. Dr. Drs. I Made Sukadana, M.Si

While the academic invitations are:

1. Dr. I Wayan Tianing, S.Si., M.Kes

2. Dr. Dra. I. A. Raka Astiti Asih, M.Si

3. Dr. Drs. I Gst. Agung Gede Bawa, M.Si

4. Dr. I. A. Gede Widihati, S.Si., M.Si

5. Dr. dr. Agung Wiwiek Indrayani, M.Kes

In this exam, Dr. Anak Agung Bawa Putra, S.Si., M.Sc., was declared to have graduated as the 353rd Graduate Doctoral Study Program of the Medical Sciences Doctoral Study Program, Faculty of Medicine, Udayana University with the predicate WITH PRAISE (CUMLAUDE)

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